Basic Prion Science “Spreads” Insight

Basic Prion Science “Spreads” Insight

Translational research used to be fun. In fact, it used to be arresting—of course, considered here in the frame of triplets and ribonucleic acids of the transfer and mRNA variety. In fact, the mind-boggling concept that someone could actually know the velocity of a ribosome trundling down a messenger RNA, like a freight car on a railway track, led me to decide at a tender age that biochemistry ...

Basic Facts for Basic Science

Overall, this outstanding text should soon become recognized as the definitive reference for the diagnosis and management of ocular trauma. The tall, narrow shape of Basic Facts for Basic Science suggests that perhaps the author intended that it be put into the pocket of one's lab coat; perhaps not, but this book is certainly appropriate for the shelf of any laboratory and for the office of any...

How basic is basic science?

Some other possible conclusions come easily to mind. Perhaps, if we’re really concerned about students’ learning evidence-based medicine, then we should teach it more or better. On the other hand I am one of many who have joined the anti-EBM movement (Norman 1999). In my view, the fundamental irony remains that, even though it made the BMJ’s ‘‘Top 15 Medical Innovations of all Time’’ list in 20...

Biochemical insight into the prion protein family

Prion protein family comprises proteins, which share not only similarity in their primary structure, but also similarity in their fold. These two groups of similarity presume a parceling in their respective biological function through the common biochemical properties. In this review, biochemical and structural similarities of PrP and two other proteins, Doppel and Shadoo, are evocated. Some ev...

Basic Science